Vitamin K antagonists: impact on hospitalizations and accesses to emergency room

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Vitamin K antagonists

For the last decades, anticoagulation for stroke prevention in atrial fibrillation (AF) as well as for the prophylaxis and long-term treatment of venous thromboembolism has been entirely based on vitamin K antagonists (VKA). Although very effective under optimal conditions, long-term treatment with these drugs is flawed by the fact that the time in the therapeutic range frequently is suboptimal...

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Quality of Anticoagulation With Vitamin K Antagonists.

BACKGROUND Vitamin K antagonists (VKA) have a narrow therapeutic range, and literature analysis reveals poor quality of anticoagulation control. We sought to assess the prevalence of poor anticoagulant control in patients under VKA treatment in the prevention of stroke for atrial fibrillation (AF). HYPOTHESIS Control of anticoagulation with VKA is inadequate in a high percentage of patients w...

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Genotype-guided dosing of vitamin K antagonists.

To the Editor: Three articles in the December 12 issue1-3 address pharmacogenetics and dosing of coumarin anticoagulants. Because it is more usual for elderly patients to have an international normalized ratio (INR) outside the targeted therapeutic range and to have frank bleeding, it would be of clinical interest to know whether the authors stratified patients by age and whether coexisting con...

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Management of excessive anticoagulant effect due to vitamin K antagonists.

Unexpectedly elevated INR values are commonly encountered in clinical practice. In the absence of bleeding, such values may be treated with either simple warfarin withdrawal or the administration of low doses of oral vitamin K. Oral vitamin K will more rapidly return the INR to the therapeutic reference interval; however, its impact on bleeding is unknown. If the INR is in excess of 10, most ex...

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ژورنال

عنوان ژورنال: European Journal of Public Health

سال: 2017

ISSN: 1101-1262,1464-360X

DOI: 10.1093/eurpub/ckx186.179